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Merck (MRK) and SciBrunch Therapeutics Co announced that they have entered into an exclusive global license agreement for SPR2015, an investigational preclinical oral KRAS G12D (ON) inhibitor.

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Merck closed an exclusive global licensing deal with SciBrunch Therapeutics for preclinical KRAS inhibitor SPR2015, paying $400 million upfront with total potential transaction value reaching $2.13 billion.

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Under the agreement, SciBrunch has granted Merck exclusive rights to develop, manufacture and commercialize SPR2015 worldwide. SciBrunch will receive an upfront payment of USD 400mln and is eligible to receive payments associated with the achievement of certain milestones related to development, commercialization and other activities across multiple indications. The total potential aggregate value of the transaction, including the upfront payment, is USD 2.13bln. The transaction has closed.

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