Absci Corporation Common Stock Morgan Stanley 24th Annual Global Healthcare Conference
Review the key takeaways and the transcript of this earnings call.
Transcript
Preview the first fifteen paragraphs, organized by speaker.
Good morning, everyone. I am Sean Lyman, Head of U.S. Midcap Biotech Equity Research here at Morgan Stanley, and welcome to Morgan Stanley Global Healthcare Conference. Before we commence, to make you aware of some important disclosures, please see those disclosures at the Morgan Stanley Research Disclosure website at www.morganstanley.com/researchdisclosures. If you have any questions, please reach out to your Morgan Stanley sales representative. For this session, we have the pleasure of hosting Absci with Founder and CEO, Sean McClain, and CFO and CBO, Zach Jonasson. Welcome and thank you both for your time today.
Yeah, thanks for having us.
Yeah. Maybe just to do me a favor and answer some macro questions before we delve into the guts of it. I guess just looking at China-originated innovation, do you have a view on that? Has it changed the way you think about your business development and R&D playbook, if at all?
Yeah, obviously, there has been a lot of activity in China, and I think it is about how you utilize China. We obviously have an AI platform, and we look at China and just how we scale our infrastructure. Not necessarily going in and buying assets there, but working with China to be able to rapidly test these hypotheses, get to yes/no answers on new targets, and even looking at how we could potentially utilize them on the clinical development side. I think that, yeah it has been very interesting to see all the activity going on, but we definitely see it as a net positive for the overall space.
Sure. Thank you. Next question is redundant for you guys because it is asking, are you implementing AI in your business?
Yeah. The third one, which policy variable are you most focused on?
I am guessing it is FDA, but thinking about FDA, Medicare negotiation, Most Favored Nation tariffs, et cetera. I would suggest it is FDA, but which policy variable are you most focused on?
Yeah, I think we are most focused on FDA. We are in the middle of our phase I/II trial for pattern hair loss. We are about to initiate a phase II trial in endometriosis. So we are following all of that policy activity. As Sean mentioned, we have a strategy to leverage execution in China, not just pre-clinical execution, but to do proof of concept work in China and phase II development going forward. So we are following all the developments in Congress and policy-wise from the administration, but we do think there is a significant opportunity there to reduce cost, increase speed, and really leverage Chinese execution.
Yep. Wonderful. Thank you, Zach. Now to get into it. I have got a series of questions here, obviously on ABS-201 in pattern hair loss to start with. The interim phase I across four single ascending dose cohorts in 32 volunteers showed no serious adverse events and an estimated half-life, I think of at least 65 days. That is a single dose estimate. How much could it move with multiple dosing and complete follow-up?
Yeah. So far the trial is going very well. We are very happy with the progress, and we are going to be announcing the phase II efficacy data in December of this year. The recruitment has been going extremely well, and safety profile really good as well, and we are really excited to be announcing this data in December.
Okay. So that is the 13-week data coming out in December?
That is correct. Okay. Got you.
Thank you. I guess the commercial thesis rests on two or three injections over six months. What is the minimum durability that still supports that profile? What happens to the pitch if it lands closer to monthly?
Well, first off, I would say we are very pleased with what we are seeing on the half-life. It looks to us like it is going to be either 2 or 3 injections over 6 months, so once every 2 months or once every 3 months. That, at least from our consumer research, is a game changer for the market because the convenience paired with the durability of the effect based on the mechanism, I think would be a completely new premium category of therapy for pattern hair loss and resonates extremely well with customers. When we talk to consumers, we have commissioned a large survey, as you know. They are very dissatisfied with standard of care. A profile that allows for a very simple injection that infrequently with durable effect is very exciting for that population.
Awesome. Thank you. We just mentioned that we are looking at the 13-week data in December. You look at width, darkness, and hair count, if I remember that correctly. I guess what is sort of the benchmark you think you need to achieve?
FULL TRANSCRIPT
Continue the full translated transcript in StockNow.
Access every statement, the English original, and speaker-by-speaker history with StockNow Pro.
View the full transcript with ProCall participants
3 people spoke on this call — only 2 are shown here.
PARTICIPANT LIST
View participant details in StockNow.
Log in to see executives and analysts, their roles, and complete speaking history.
Log in to view all participantsKeep exploring
