Rani Therapeutics Holdings, Inc. Class A Common Stock Chardan's 10th Annual Healthcare Conference

Absolutely. First, Andreas, thank you for giving us the opportunity to be here and have this conversation. Rani Therapeutics is a clinical-stage biotech, and I promise you, at a minimum, you will not hear this story again today or any other day. What we've developed is a platform technology for the oral administration of virtually any biologic with bioavailability that is equivalent to a subcutaneous injection. It doesn't matter if you deliver a monoclonal antibody, a protein, a peptide, an oligo. We've done all of those, and they're all equivalent. As Andreas said, that's been called the holy grail of drug delivery. The state of the art before us was permeation enhancers that really are only geared towards delivering small peptides. Even there, you get sub 1% bioavailability, incredibly high variability, and food effect.

The reason we've been able to make it work is we are working with the anatomy and physiology of the gut as opposed to against it. What we've developed is essentially a swallowable auto-injector. It looks like a pill. A patient swallows it, and when it gets to the small intestines, there's a reaction, an Alka-Seltzer reaction that occurs that inflates and aligns a balloon. There's a microsyringe inside of the balloon that delivers the drug through an injection, pain-free, because there's no sharp pain receptors in the gut. The needle itself that does this dissolves, so we don't even leave a sharp in the body. The balloon deflates and is excreted out. I can see people's faces. It sounds like science fiction. It is very real. We've been through four clinical studies, a repeat dose study.

Over 250 pills orally administered, showing incredibly high bioavailability, whether it's a peptide or an antibody.

Any? Any. We've delivered STELARA in a pill in humans.

We've done factor VIII, which is a 300 kilodalton molecule. Literally anything. There's no limitation. We'll take questions. Sure. You mentioned needle.

How do you compact There's a balloon that inflates and aligns, and it provides apposition.

We don't have a picture of it, but it has a hump at the back that provides sort of back force, and then the needle comes out very quickly, and the drug is delivered into the intestinal wall, pain free. It comes out in less than a second, and then the needle dissolves about 30 seconds later.