Niagen Bioscience, Inc. Common Stock Canaccord Genuity's 46th Annual Growth Conference

NAD stands for nicotinamide adenine dinucleotide. It's a coenzyme found in all living cells, plant and animal cells, and is vital to all important metabolic processes within that cell, but notably energy metabolism, mitochondrial function, the process by which mitochondria convert nutrients from food and oxygen from air into energy, but also the processes of identifying problems in the cell and repairing the problems in the cell. That could be a gene mutation, it could be inflammation, it could be oxidative stress, it could be actual physical damage, it could be the presence of virus. But there are mechanisms within the cell that will correct damage when the cell is damaged, and NAD is vital to those processes. Niagen Bioscience is probably indisputably the leading authority globally in NAD science. We have a large portfolio of molecules that elevate NAD and impact NAD.

We have a scientific advisory board of world-renowned researchers recognized globally as the leading scientists in mitochondrial function and in NAD metabolism in general, as well as internal scientists and relationships with external scientists doing much research. We've published over 500 studies, clinical and pre-clinical. Our flagship ingredient is something called nicotinamide riboside. We call it Niagen, which is the safest, most researched, and most effective way to elevate NAD in damaged cells, nicotinamide riboside. We have, I think, 47 peer-reviewed published clinical studies showing that Niagen elevates NAD safely, and these studies not only show that it elevates NAD, but they've gone deeper into actual therapeutic benefits. Virtually every age-related condition that you can imagine or think of is also associated with a decline in NAD.

As we age, our NAD levels decline fairly dramatically, and when a cell is damaged, it declines even more dramatically, and it's logical that that would be the case because the cell's trying to repair itself and consuming energy to repair itself. We've shown that not only is there a decline in NAD, but by elevating NAD with Niagen, which is offered in multiple modalities, it actually can be therapeutic for that cell, or prophylactic, can prevent age-related damage. NAD is becoming extremely popular, and we've built a company not only around this portfolio of molecules that manage NAD levels, but also we operate in many different commercial verticals, the largest one of which is just a dietary supplement. We call it Tru Niagen. It's one of the largest dietary supplement SKUs in the world right now. But it's really pretty much all we sell.

We don't sell a whole series of other dietary supplements. We really just sell that. We also offer Niagen as an IV or an injection, which required approval of sorts from the FDA because it's considered a drug and needs to be pharmaceutical-grade material. So we have that as a second vertical where you can get an at-home injection of Niagen or go to a clinic and get an IV of Niagen. We also sell Niagen as an ingredient to certain other dietary supplement companies and food companies. Finally, and perhaps the most exciting, is we also are developing Niagen and our other molecules in our portfolio for diseases. There are certain diseases where children age so rapidly that they often actually die of old age by the time they're teenagers, sometimes called the Benjamin Button diseases.

It turns out that many of these kids have actually non-detectable levels of NAD. It's a good indication of the relationship between the way the body ages and what your NAD level is. So in a sense, we all have forms of these diseases because we're all, as we age, depleting our NAD, and we're getting older. So we've already done numerous studies, pre-clinical and clinical, on several of these diseases, one in particular called ataxia-telangiectasia, where we've shown a meaningful therapeutic benefit to these kids who take oral version of Tru Niagen who are diagnosed with these diseases. So we see this orphan disease, particularly ataxia-telangiectasia, as a very important strategic initiative for our company. It's an NAD platform company. Our flagship molecule is nicotinamide riboside, but we have many others, and we pursue these multiple verticals, and that's basically Niagen Bioscience.

The consumer business is mostly Tru Niagen. That's a dietary supplement. Of course, we also have the ingredient business. The sales in 2025 were approximately just a shade under $130 million. The majority of that, close to $100 million of that, was just straight Tru Niagen sales, and the balance was mostly ingredient sales, supplying to other dietary supplement companies. We mostly are an e-commerce business, our own website, truniagen.com, as well as amazon.com. Amazon is larger than our website. There is some retail, increasing amounts of retail in the U.S. There's a partner in Hong Kong called Watsons that's a retail partner that does also significantly well, and other regions of Asia as well, Singapore, Macau. We do cross-border sales into certain other countries in Asia and increasingly growing in Europe.

Leading with the topical, it turns out that there are many different tissue types, cell types that have a high concentration of the enzyme that is the pathway for nicotinamide riboside to enter cells. Turns out that muscle cells have a high concentration of that pathway. It is called the NRK pathway, but also skin cells do as well. Two areas where there is highest likelihood to show a benefit to elevating NAD with Niagen would be muscle cells and skin cells. There is also indication in heart cells and brain cells as well, but skin cells in particular seem to have a high concentration of these NRK enzymes. We have done numerous studies on Niagen on skin cells, and it turns out that when you elevate NAD in skin cells through Niagen, it has a significant improvement in elasticity, in wrinkle depth, and on age spots.

What is challenging is to make sure that just a simple topical application of Niagen will actually penetrate the skin and elevate NAD. We have data that suggests that in fact it does. As a result, as a test, we launched a product that we call Niagen NanoCloud, which are tiny little pillows. They are little powder forms of Niagen surrounded by hyaluronic acid covering. You just put it in the palm of your hand and mix it with water or cream and apply it to your face. In fact, we have done some user studies as a result. It seems to work really well.

There was a study published, or at least made public, the abstract of which last weekend by Estée Lauder, a skincare company that compared a topical Niagen to a very popular ingredient called niacinamide, which is one of the most popular ingredients in the skincare business, and Niagen defeated it handily. We know we have a much superior ingredient already than niacinamide, and our Niagen NanoCloud product sold extremely well. We just made a few thousand of them. They sold out in a couple of months, so we will relaunch it in October. We also plan to launch an actual cream itself in April of next year. Not a Niagen NanoCloud, but an actual moisturizing product that you can apply directly to the skin. We are very excited about that, and there is reason to believe why this would actually work and have an impact on the skincare industry in general.

Several of the larger, not just Estée Lauder, but other companies as well, are interested in studying and doing supply agreement deals with us where we would supply Niagen as an ingredient to them to put into their products.